Use of excipients from plant origin has gained importance in formulation of dosage form due to their easy availability, eco-friendly nature and cost effectiveness compared to synthetic additives. Mucoadhesive polymers that bind to epithelial surface are useful in drug delivery for purpose of increasing the intimacy and duration of contact of drug with absorbing membrane. An attempt has been made to isolate and characterize mucilage from Coccinia grandis (Ivy Gourd). Isolated mucilage was tested for various parameters as per Indian Pharmacopoeia to confirm the characteristics of mucilage. The mucoadhesive efficiency of separated mucilage has been compared with synthetic polymer carbopol by performing tests for in vitro bioadhesion force and in vitro residence time. The study revealed that mucilage powder in 7% concentration range showed results comparable to carbapol 934. Thus, it can be concluded that mucilage from Coccinia grandis can be a good option for synthetic polymers with mucoadhesive properties.
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